AA can cause a considerable burden that extends beyond hair loss1-4

Learn about the physical and social impact of AA

Watch a video to hear a real patient perspective on AA

Learn about the physical and social impact of AA

Watch a video to hear a real patient perspective on AA

The physical and social impact of AA

Physical Impact of AA Beyond Hair Loss

  • Complications related to hair loss on the scalp include sunburn and sensitivity to temperature2
  • Patients who experience loss of eyebrows, eyelashes, or nose hair may experience eye and nasal irritation1,5-7
  • AA may also be accompanied by nail changes or abnormalities, including nail pitting, splitting, and pain1,2,5
  • Patients with AA have been shown to have comorbidities with other autoimmune disorders and atopic diseases4,8

Social Impact of AA

  • For some patients, experience of AA hair loss has been linked to a sense of changing self-identity1,2,9
  • In a US survey of 216 adult patients with AA2:
    • 62% of patients reported withdrawing from activities
    • 54% reported reducing interactions with friends because of their AA
    • Of the employed patients (n=132), 45% reported missing time from work because of AA
  • Some patients with AA have reported the loss of defining facial features, including eyebrows and eyelashes, as socially bothersome6,9

Real patient perspectives on the burden AA can have on daily life7:

Watch Britt Craiglow, MD, discuss the impact of AA
with Lilly, a 17-year-old patient, and her mother:

Patient Perspectives on the Impact of AA7


Selected patient quotes from a 2017 US Food and Drug Administration (FDA) public meeting.7

References: 1. Aldhouse NVJ, Kitchen H, Knight S, et al. “‘You lose your hair, what’s the big deal?’ I was so embarrassed, I was so self-conscious, I was so depressed:” a qualitative interview study to understand the psychosocial burden of alopecia areata. J Patient Rep Outcomes. 2020;4(1):76. 2. Mesinkovska N, King B, Mirmirani P, Ko J, Cassella J. Burden of illness in alopecia areata: a cross-sectional online survey study. J Invest Dermatol Symp Proc. 2020;20(1):S62-S68. 3. Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397-403. 4. Huang KP, Mullangi S, Guo Y, Qureshi AA. Autoimmune, atopic, and mental health comorbid conditions associated with alopecia areata in the United States. JAMA Dermatol. 2013;149(7):789-794. 5. Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP. Alopecia areata. Nat Rev Dis Primers. 2017;3:17011. 6. Wyrwich KW, Kitchen H, Knight S, et al. The role of patients in alopecia areata endpoint development: understanding physical signs and symptoms. J Investig Dermatol Symp Proc. 2020;20(1):S71-S77. 7. US Food and Drug Administration (FDA). The Voice of the Patient: Alopecia Areata; 2018. 8. Kridin K, Renert-Yuval Y, Guttman-Yassky E, Cohen AD. Alopecia areata is associated with atopic diathesis: results from a population-based study of 51,561 patients. J Allergy Clin Immunol Pract. 2020;8(4):1323-1328.e1. 9. Hunt N, McHale S. Reported experiences of persons with alopecia areata. J Loss Trauma. 2004;10:33-50.